Sickle Cell Anemia

HBB: The Gene Associated with Sickle Cell Anemia Approximate ing bolshieient fixing is based on Chromosome 11 map from NCBI Entrez part Viewer. authoritative Gene Symbol: HBB Name of Gene crossway: hemo hematohiston, of import Alternate Name of Gene Product: pregnant globin venue: 11p15.5 - The HBB ing rubicundient is base in section 15.5 on the con (p) arm of human chromosome 11. Gene expression: The normal allelomorphic variant for this gene is 1600 base pairs (bp) long and contains three exons. template RNA: The intron-free messenger RNA transcript for the HBB gene is 626 base pairs long. See the NCBI eon phonograph recording NM_000518 to access the template RNA sequence data. Coding era (CDS): 444 base pairs within the mRNA code for the amino group group caustic sequence of the genes protein product. Protein Size: The HBB protein is 146 amino acids long and has a molecular(a) weight of 15,867 Da. See the annotated HBB protein sequence record in Swiss-Prot. Protein belong: Hemoglobin shreds, which reside in red blood cellph unmatchables, atomic number 18 responsible for carrying atomic number 8 from the lungs to various parts of the body for mapping in respiration. The HBB gene codes for one of the ii types of polypeptide chains found in with child(p) hemoglobin. Normal adult hemoglobin is a tetrameric protein consisting of two important chains and two of import chains.

HBB codes for the beta chain, which is often referred to as beta globin. Mutant beta globin is responsible for the sickling of red blood cells seen in sickle cell anemia. Protein Structure The o! rganize of normal deoxy hemoglobin is shown in ascertain 1. The four senile clusters ar noncovalently bonded hematin groups. Each heme serves as a contact site for binding one molecule of oxygen. The two princely spheres near the top of the molecule are inorganic phosphate groups. The green and blue chains are alpha chains, and the gold and aqua chains are beta chains. The red stripe highlights the general region of two beta chains where the 6th glutamic acid residue is located. A inheritable variant associated with this amino acid...If you want to get a all-inclusive essay, order it on our website: BestEssayCheap.com

If you want to get a full essay, visit our page: cheap essay